New interfering RNA, useful for treatment and prevention of diseases caused by morbilliviruses, are directed against the mRNA from the viral nucleoprotein gene

摘要

Interfering RNA (A) directed against a region (R) of the mRNA of the N gene, which encodes the nucleoprotein of a morbillivirus, is new. (R) contains the motif defined by Seq. (1) RRWYNNRHUGGUUHGARA (1) where R = A or G; Y = C or U; W = A or U; H = A, C or U; N = A, C, G or U. An independent claim is included for an expression vector that contains a DNA sequence encoding (I), transcribable to (A), under control of a promoter. ACTIVITY : Virucide. MECHANISM OF ACTION : Vaccine; inhibition of viral replication by RNA interference.