<p>The present invention relates to novel isolated siRNAs comprising a sense RNA strand and a complementary antisense RNA strand which together form an RNA duplex, characterized in that the sense RNA strand comprises a sequence which has at most one nucleotide that is distinct in relation to a fragment of 14 to 30 contiguous nucleotides of the nucleotide sequence of exon F of the gene encoding the myosin Va protein, and also to compositions comprising at least one such siRNA, and to the use of at least one such siRNA as a cosmetic or therapeutic agent for skin depigmentation.</p>
申请公布号
WO2007068704(A1)
申请公布日期
2007.06.21
申请号
WO2006EP69618
申请日期
2006.12.12
申请人
PIERRE FABRE DERMO-COSMETIQUE;SCHMITT-MILAS, ANNE-MARIE;LAMBERT, JO;WESTBROEK, WENDY;VAN GELE, MIREILLE