USE OF INHIBITORS OF THE UBIQUITIN PROTEASOME PATHWAY FOR INCREASING CONTRACTILITY OF THE HEART
摘要
The present invention describes novel uses for inhibitors of the ubiquitin proteasome degradative pathway. In particular it describes methods for improving cardiac function, increasing alpha myosin levels in the heart, and increasing SERCA levels in the heart. The invention also provides methods for treating cardiac hypertrophy through inhibiton of the ubiquitin proteasome.
申请公布号
WO2007011757(A8)
申请公布日期
2007.06.21
申请号
WO2006US27443
申请日期
2006.07.12
申请人
MYOGEN, INC.;BUSH, ERIK;GORCZYNSKI, RICK;KOCH, KEITH;MCKINSEY, TIMOTHY, A.
发明人
BUSH, ERIK;GORCZYNSKI, RICK;KOCH, KEITH;MCKINSEY, TIMOTHY, A.