MONITORING OF INTRACELLULAR MITOCHONDRIAL LOCALIZATION

摘要

It is intended to provide a method of detecting a change in the mitochondrial localization state in a living cell. By using a surface plasmon resonance device, a change in the surface plasmon resonance angle caused by a change in the mitochondrial localization state in the living cell is detected. Further, one or more substances are administered to the living cell and a change in the surface plasmon resonance angle caused by a change in the mitochondrial localization state is detected. As the step of detecting a change in the surface plasmon resonance angle caused by a change in the mitochondrial localization state, use can be made of a step which comprises detecting a change in the surface plasmon resonance angle within a period of time wherein this change is caused exclusively by a change in the mitochondrial localization state, preferably a step which comprises detecting the change after a lapse of 20 minutes from the administration of the substance(s), more preferably after a lapse of 30 minutes therefrom and more preferably after a lapse of 35 minutes therefrom.