METHOD FOR PRODUCING OPTICALLY ACTIVE (4E)-5-CHLORO-2-ISOPROPYL-4-PENTENOIC ACID OR BASIC AMINO ACID SALT THEREOF

摘要

Disclosed is a method for producing an optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid, a basic amino acid salt thereof or an optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid ester with high yield and high optical purity by simple operations. Specifically, a basic amino acid salt of an optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid is precipitated from a solvent solution containing an optical isomer mixture of (4E)-5-chloro-2-isopropyl-4-pentenoic acid and an optically active basic amino acid or a salt thereof, and then the basic amino acid salt of the optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid is subjected to a desalting reaction, thereby obtaining an optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid. In addition, an optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid ester is obtained through an esterification reaction of such an optically active (4E)-5-chloro-2-isopropyl-4-pentenoic acid.