COMPOSITION FOR ANTIHYPERTENSIVE EFFECT COMPRISING A RHEI RHIZOMA EXTRACT OR ACTIVE COMPOUNDS ISOLATED THEREFROM

摘要

An anti-hypertensive composition comprising the extract of Rhei rhizoma or active compounds isolated therefrom is provided to induce smooth muscle relaxation of the blood vessel, so that the composition is useful for treatment of hypersensitive and hypersensitive complications. The anti-hypertensive composition comprises the extract of Rhei rhizoma or active compounds isolated therefrom including piceatannol represented by the formula(1), epsilon-viniferin represented by the formula(2), physcion represented by the formula(3) or emodin represented by the formula(4) as an effective ingredient. The Rhei rhizoma extract is prepared with an organic solvent of methanol, ethanol, butanol, dichloromethane or ethylacetate; and the active compounds are isolated from the Rhei rhizoma extract by subjecting the Rhei rhizoma extract to reverse phase or silica gel column chromatography.