| 摘要 |
Peptides and peptidomimetics capable of modulating apoptosis through their interaction with cellular LAPs (inhibitor of apoptosis proteins) are disclosed. The peptides and mimetics are based on the N-terminal tetrapeptide of LAP-binding proteins, such as Smac/DLABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptides and peptidomimetics for therapeutic purposes and for rational drug design.
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