COMBINATION THERAPY USING BUDESONIDE AND ANTISENSE OLIGONUCLEOTIDE TARGETED TO IL4-RECEPTOR ALPHA

摘要

Provided herein is a method for reducing the amount of steroid required for the prevention, amelioration and/or treatment of pulmonary inflammation and/or airway hyperresponsiveness, comprisi administration of the steroid and an oligonucleotide targeted to IL-4R alpha. Also described is a method for the prevention, amelioration and/or treatment of pulmonary inflammation and/or airway hyperresponsiveness comprising administration of a corticosteroid and an oligonucleotide targeted to EL 4R alpha. Further provided are compositions comprising a corticosteroid and an EL-4R alpha targeted antisense oligonucleotide.