| 摘要 |
Novel estrogenic compounds of Formula I are provided. wherein the bond represented by the wavy line may be a single or double bond such that when the wavy line is a single bond, R<SUB>1 </SUB>is selected from the group consisting of hydrogen, sulfate and glucoronate or other esters, and when the wavy line is a double bond, R<SUB>1 </SUB>does not exist; R<SUB>2 </SUB>is lower alkyl; R<SUB>3 </SUB>may be selected from the group consisting of hydrogen, sulfate, or glucuronide or other esters; and R<SUB>4 </SUB>through R<SUB>13 </SUB>may independently be selected from the group consisting of hydrogen, hydroxy, ketone, lower alkyl, lower alkoxy, halogen, and carbonyl groups and R<SUB>14 </SUB>is selected from the group consisting of hydrogen, sulfate and glucoronide and other esters. When R<SUB>1 </SUB>is hydroxy, the hydroxy or ester substituent may have either an alpha or a beta orientation. Compositions of matter including compounds of the present invention are also provided as are methods of treating mammals in need of treatment using compounds of the present invention.
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