发明名称 |
PREVENTION AND TREATMENT OF HYPERGASTRINEMIA |
摘要 |
<p>Serum-associated hypergastrinemia is treated by administration of gastrin active or passive immunization. An anti-gastrin immunogenic composition containing a gastrin G17 or G34 peptide fragment which is amino acid spacer-linked to an immunogenic carrier, is administered so as to effectively neutralize the circulating gastrin hormone, and moreover, inhibit autocrine activity by progastrin such as Gly-extended G17, and amidated G17, in patients with pernicious anemia. Moreover, the method includes administration of a therapeutically effective amount of anti-G17 or anti-G34 antibodies which may be in humanized form. Finally, the method provides ameliorating treatment of hypergastrinemic effects of proton pump inhibitors or H<SUB>2 </SUB>histamine receptor blocking agents or antagonists, in addition to treatment of hypergastrinemia caused by diseases such as pernicious anemia.</p> |
申请公布号 |
EP1077721(B8) |
申请公布日期 |
2007.06.20 |
申请号 |
EP19990924258 |
申请日期 |
1999.05.14 |
申请人 |
RECEPTOR BIOLOGIX, INC. |
发明人 |
GEVAS, PHILIP, C.;GRIMES, STEPHEN;KARR, STEPHEN;MICHAELI, DOV;WATSON, SUSAN |
分类号 |
A61K39/385;A61K38/00;A61K38/22;A61K47/48;A61P7/00;A61P37/04;C07K7/06;C07K7/08;C07K14/595;C07K16/26;C07K16/40 |
主分类号 |
A61K39/385 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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