Oral delivery of protein drugs using microemulsion

摘要

A novel method of encapsulating a drug, preferably a peptide and/or protein drug in a biodegradable complex, which comprises: a) a biodegradable polymer that contains primary amine groups such as chitosan oligosaccharide, b) an organic carboxylic acid such as oleic acid, and c) optionally, an emulsifying agent such as plurol (glycerol-6-dioleate). The formula results in the formation of a continuous oily phase containing nanoparticles having the drug encapsulated therein.