摘要 |
<p>Process :- where A is an anion. Blood pressure lowering activity without cardiac depression. Vincamin Salt I II (A=I) Toxicity (rats) LD50 40 mg/kg. 16 mg/kg Blood press. lowering ED50 (cats) 4.0 " 1.8 " Therapeutic Ratio ED50/LD50 0.1 0.11 A soln. of II (0.31 g., 0.001 mol.) in acetone (20 ml) was prepd. by warming. Methyl iodide (5 ml) was added and the mixture was heated for 1 hr. under reflux. At the end of this period the product begins to ppte. After cooling I (A = iodine) (0.35 g), m.p. 250-252 deg. was obtd.</p> |