4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them

摘要

The invention relates to 4-substituted quinoline compounds of general formula: which are active as antimicrobials, in which: X₁, X₂, X₃, X₄ and X₅ is C-R'₁, to C-R'₅ respectively, or alternatively at most one represents N, Y represents CHR, CO, CROH, CRNH₂, CRF or CF₂, R being a hydrogen or alkyl, m is 1, 2 or 3 and n is 0, 1 or 2, Z is CH₂ or Z is O, S, SO, SO₂ and, in this case, n is equal to 2, R₂ is -CO₂R, -CH₂CO₂R, -CH₂-CH₂CO₂R, -CH₂OH or -CH₂-CH₂OH, wherein R is as defined above, R₃ represents phenyl, heteroaryl or alk-R^o₃, where alk is alkyl and R^o₃ represents various groups, where appropriate containing oxygen, sulfur or amine, in their enantiomeric or diastereoisomeric forms or their mixtures, and/or where appropriate in the syn or anti form or their mixtures, and their salts.