Quinazoline derivatives as medicaments

摘要

Quinazoline derivatives have the formula: or the pharmaceutically acceptable salts thereof; wherein each of Z⁵, Z⁶, Z⁷ and Z⁸ is N or CH and wherein one or two Z⁵, Z⁶, Z⁷ and Z⁸ are N and wherein two adjacent Z positions cannot be N; wherein m and n are each independently 0-3; wherein R¹ is independently OH, SH, NH₂, OR, SR, NHR, halo or R-halide; wherein two adjacent R¹ groups may be joined to form an aliphatic hetero cycle ring of 5-6 members; wherein R² is independently R, halo, R-halide, OR-halide, NH₂, CONH₂ or CONHR; wherein R is optionally substituted C₁-C₁₂ alkyl, C₁-C₁₂ alkenyl, C₁-C₁₂ alkynyl, or aryl C₁-C₁₂ alkyl, containing 0-4 heteroatoms in place of a carbon in the carbon backbone, where the optional substituents are -O, -N, or OH; and wherein R³ is H or CH₃. Such compounds are useful in pharmaceutical compositions and methods of treating conditions characterized by enhanced TGFbeta activity.