Kinase inhibitors and associated pharmaceutical compositions and methods of use

摘要

The invention provides novel compounds useful as kinase inhibitors or as starting materials And/or intermediates in the synthesis of compounds useful as kinase inhibitors. The compounds have The general structure of formula (I) wherein A is a 3- to 8-membered ring, optionally substituted and/or heteroatom-containing, and R¹, R², R³, R⁴, R⁵, R⁶, X, Y, Z, p, and q are as defined herein. The compounds may also be in the form of a salt, ester, amide, or other analog. In preferred compounds, A is a 5- to 8-membered ring, R¹ is hydrogen, q is a bond, X is N, Y is C-O, Z is N, R² contains a terminal amino moiety, p is 1, and R³ and R⁴ are linked to form a pyrrole ring fused to a second cyclic group. Pharmaceutical compositions and methods for using the compounds are also provided.