AN ISOLATED BRUCELLA DNA FRAGMENT, A RECOMBINANT DNA CONSTRUCT CONTAINING THE SAME AND A METHOD FOR PRODUCING BRUCELLA PEPTIDE

摘要

Live Brucella vaccines and methods for preparing the live vaccines protective against brucellosis are described. The vaccines are prepared by introducing a deletion in the rfbU gene of a strain of Brucella which results in attenuation of the strain while retaining the desired immunogenicity to initiate a protective immunogenic response. Other strains with varying levels of attenuation are described.