IMMUNOGENE ZUSAMMENSETZUNGEN GEGEN EINE HELICOBACTERINFEKTION, VERWENDUNG VON POLYPEPTIDEN IN DIESEN ZUSAMMENSETZUNGEN UND NUKLEINSÄURENDIE BESAGTE POLYPEPTIDE KODIEREN

摘要

There is provided an immunogenic composition capable of inducing protective antibodies against Helicobacter infection characterized in that it comprises:i) at least one sub-unit of a urease structural polypeptide from Helicobacter pylori, or a fragment thereof, said fragment being recognized by antibodies reacting with Helicobacter felis urease, and/or at least one sub-unit of a urease structural polypeptide from Helicobacter felis, or a fragment thereof, said fragment being recognized by antibodies reacting with Helicobacter pylori urease;ii) and/or, a heat shock protein (Hsp), or chaperonin, from Helicobacter, or a fragment of said protein.The preparation, by recombinant means, of such immunogenic compositions is also provided.