发明名称 |
Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination |
摘要 |
Conjugates of hydroxyalkyl starch and a protein are provided. The conjugates are formed by a reductive amination reaction between at least one aldehyde group or keto group or hemiacetal group of the hydroxyalkyl starch or of a derivative of the hydroxyalkyl starch, and at least one amino group of the protein, so that the hydroxyalkyl starch or the derivative thereof is covalently linked to the protein via an azomethine linkage or a amino linkage. Methods of producing these conjugates and specific uses of the conjugates also are provided.
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申请公布号 |
US2007134197(A1) |
申请公布日期 |
2007.06.14 |
申请号 |
US20060518352 |
申请日期 |
2006.09.08 |
申请人 |
EICHNER WOLFRAM;ORLANDO MICHELE;ZANDER NORBERT;CONRADT HARALD S;HACKET FRANK;LANGER KLAUS;FRANK RONALD |
发明人 |
EICHNER WOLFRAM;ORLANDO MICHELE;ZANDER NORBERT;CONRADT HARALD S.;HACKET FRANK;LANGER KLAUS;FRANK RONALD |
分类号 |
A61K38/19;A61K38/18;A61K38/20;A61K38/21;A61K38/36;A61K38/38;A61K38/42;A61K38/44;A61K38/48;A61K38/55;A61K47/48;A61K51/06;A61K51/08;C07K14/00;C08B31/00;C08B31/18 |
主分类号 |
A61K38/19 |
代理机构 |
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代理人 |
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地址 |
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