Provided are methods for diagnosing sporadic and familial forms of amyotrophic lateral sclerosis ("ALS") that detect conformers or conformer patterns of the copper-zinc superoxide dismutase-1 ("SOD-1") enzyme that are common to sporadic or familial ALS individuals but distinct from SOD-1 conformers of normal individuals. Methods of identifying candidate drugs that modulate SOD-1 conformer formation also are provided.
申请公布号
WO2007067900(A2)
申请公布日期
2007.06.14
申请号
WO2006US61632
申请日期
2006.12.05
申请人
PROSETTA CORPORATION;LINGAPPA, VISHWANATH, R.;LIU, JIAN;GRUZMAN, ARIE, LEV
发明人
LINGAPPA, VISHWANATH, R.;LIU, JIAN;GRUZMAN, ARIE, LEV