发明名称 |
SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: BLENDED SELEX |
摘要 |
A method is described for generating blended nucleic acid ligands containing non-nucleic acid functional units. Specifically, a SELEX identified RNA ligand to the integrin gpIIbIIIa is conjugated to the peptide Gly-Arg-Gly-Asp-Thr-Pro (SEQ ID NO:1). This blended RNA ligand inhibits the biological activity of gpIIbIIIa with high specificity. Also described is a single-stranded DNA ligand to elastase coupled to N-methoxysuccinyl-Ala-Ala-Pro-Val-chloromethyl ketone (SEQ ID NO:2). This elastase blended nucleic acid ligand inhibits the biological activity of elastase.
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申请公布号 |
US2007134715(A1) |
申请公布日期 |
2007.06.14 |
申请号 |
US20070668337 |
申请日期 |
2007.01.29 |
申请人 |
GILEAD SCIENCES, INC. |
发明人 |
BIESECKER GREG;JAYASENA SUMEDHA D.;GOLD LARRY;SMITH DREW;KIRSCHENHEUTER GARY P. |
分类号 |
C12Q1/68;C07H21/02;C07H21/04;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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