E-fluoro-4-(pyridin-2-yl)-piperidine-1-carboxamide derivatives and related compounds which modulate the function of the vanilloid-1 receptor (vr1) for the treatment of pain

摘要

Compounds of formula (I): wherein: A¹ is phenyl, a six-membered aromatic heterocycle containing one, two or three nitrogen atoms, or a five-membered aromatic heterocycle containing up to four heteroatoms chosen from O, N and S, at most one heteroatom being O or S; A² is phenyl, a six-membered aromatic heterocycle containing one, two or three nitrogen atoms, or a five-membered aromatic heterocycle containing up to four heteroatoms chosen from O, N and S, at most one heteroatom being O or S; L is a bond or C_1-6alkylene; R¹ and R² independently chosen from hydrogen and C_1-6alkyl or R¹ and R² may, together, form a methylene or ethylene bridge; W is halogen, C_1-6alkyl, haloC_1-6alkyl, C_1-6alkoxy or haloC_1-6alkoxy; X is O, S or NR³ or X, together with the atom to which it is attached, and Y, form an unsaturated five-membered ring together with A²; Y is a bond, C_1-4alkylene, NH or NH(CH₂)_1-3; or a pharmaceutically acceptable salt thereof; other substituents are defined in claim 1 ; which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).