MODULE-LEVEL ANALYSIS OF PERIPHERAL BLOOD LEUKOCYTE TRANSCRIPTIONAL PROFILES

摘要

The present invention includes an apparatus, system and method for the
development and use of transcriptional
modules by obtaining individual gene expression levels from cells obtained
from one or more patients with a disease or condition;
recording the expression value for each gene in a table that is divided into
clusters; iteratively selecting gene expression values for
one or more transcriptional modules by: selecting for the module the genes
from each cluster that match in every disease or condition;
removing the selected genes from the analysis; and repeating the process of
gene expression value selection for genes that cluster in
a sub-fraction of the diseases or conditions; and iteratively repeating the
generation of modules.