发明名称 |
CROSS-LINKING REAGENTS FOR HEMOGLOBIN AND HEMOGLOBIN PRODUCTS CROSS-LINKED THEREWITH |
摘要 |
<p>A process for efficiently preparing bis-tetrameric hemoglobin in which the tetramers are specifically linked at predetermined sites on the ß-sub-units and in which the tetramers themselves are effectively bonded to prevent dissociation into dimeric aß-hemoglobin sub-units therefrom is provided. The process uses as cross-linking reagent a hexafunctional aromatic acyl phosphate containing amide groups. The concept is to use a cross-linking reagent which has an excess of site-specific hemoglobin reacting groups, namely six acyl phosphate groups, so that at least four of them will react site specifically to form the bis-tetrameric product of particular therapeutic interest.</p> |
申请公布号 |
WO2007065265(A1) |
申请公布日期 |
2007.06.14 |
申请号 |
WO2006CA01998 |
申请日期 |
2006.12.07 |
申请人 |
HU, DONGXIN;KLUGER, RONALD |
发明人 |
KLUGER, RONALD;HU, DONGXIN |
分类号 |
A61K35/14;C07K14/805;A61K38/16;A61K49/06;C07F9/09 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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