发明名称 |
HEPARANASES AND SPLICE VARIANTS THEREOF, PONUCLEOTIDES ENCODING THEM AND USES THEREOF |
摘要 |
The invention relates to novel heparanases, heparanase splice variants, and to polynucleotides encoding them. Particularly, the invention relates to Spalax heparanases, and to Spalax and human heparanase splice variants. Heparanase splice variants can be used, for example, to modulate the activity of heparanase in diseases disorders or conditions caused by or associated with the enzymatic activity of heparanase. For instance, a splice variant capable of down regulating the activity of heparanase can be used to treat primary tumors and/or to prevent or treat metastasis.
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申请公布号 |
WO2007034480(A3) |
申请公布日期 |
2007.06.14 |
申请号 |
WO2006IL01099 |
申请日期 |
2006.09.20 |
申请人 |
CARMEL-HAIFA UNIVERSITY ECONOMIC CORP. LTD;RAPPAPORT FAMILY INSTITUTE FOR RESEARCH IN THE MEDICAL SCIENCES;NASSER, NICOLA J.;AVIVI, AARON;VLODAVSKY, ISRAEL;NEVO, EVIATAR |
发明人 |
NASSER, NICOLA J.;AVIVI, AARON;VLODAVSKY, ISRAEL;NEVO, EVIATAR |
分类号 |
A61K38/00 |
主分类号 |
A61K38/00 |
代理机构 |
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地址 |
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