GENETICALLY RECOMBINANT ANTI-PERP ANTIBODY

摘要

It has been demanded to develop an antibody capable of binding to a polypeptide encoded by a human PERP (p53 apoptosis effector related to PMP-22) gene which is believed to be involved in the development of cancer or the like. Thus, disclosed is a genetically recombinant antibody which has a variable region bearing no consensus sequence to which an N-binding sugar chain can be bound, can recognize specifically the conformation of an extracellular region of a polypeptide encoded by the PERP gene, and can bind to the extracellular region. The antibody is useful for the treatment of various diseases in which a polypeptide encoded by the PERP gene is expresses.