The present invention relates to novel peptides capable of binding to a receptor of the fibroblast growth factor receptor family (FGFRs) and modulating activity of said receptor. The peptides of the invention are fragments of FGFRs, wherein said fragments comprise amino acid residues involved in the reciprocal interaction of the Immunoglobulin-like modules 2 (Ig2) and Immunoglobulin-like module 1 (Ig1) of FGFR. The invention discloses amino acid sequences derived from the reciprocal Ig 1 -to-lg2 binding site of FGFR and relates to use of the peptides comprising said amino acid sequences for the treatment of different pathological conditions, wherein FGFRs play a prominent role. Accordingly, pharmaceutical compositions comprising the compounds of the invention are also concerned.
申请公布号
WO2007045247(A3)
申请公布日期
2007.06.14
申请号
WO2006DK00585
申请日期
2006.10.17
申请人
ENKAM PHARMACEUTICALS A/S;BEREZIN, VLADIMIR;KISELYOV, VLADISLAV, V.;BOCK, ELISABETH
发明人
BEREZIN, VLADIMIR;KISELYOV, VLADISLAV, V.;BOCK, ELISABETH