发明名称 |
HISTOLOGISCHE BEWERTUNG DES NUKLEARPLEOMORPHISMUS |
摘要 |
A method of histological assessment of nuclear pleomorphism to identify potential cell nuclei divides image data into overlapping sub-images. It uses principal component analysis to derive monochromatic image data, followed by Otsu thresholding to produce a binary image. It removes image regions at sub-image boundaries, unsuitably small image regions and holes in relatively large image regions. It then reassembles the resulting sub-images into a single image. Perimeters (P) and areas (A) of image regions which are potential cell nuclei are determined and used in calculating nuclear shape factors P2/A. Nuclear pleomorphism is assessed as relatively low, moderate or high according to whether predetermined shape factor thresholds indicate a mean cell nucleus shape factor for an image is relatively low, moderate or high. |
申请公布号 |
DE60313662(D1) |
申请公布日期 |
2007.06.14 |
申请号 |
DE2003613662 |
申请日期 |
2003.11.13 |
申请人 |
QINETIQ LTD. |
发明人 |
PETROU, MARIA;KESIDIS, ANASTASIOS;VARGA, MARGARET JAI;DUCKSBURY, PAUL GERARD |
分类号 |
G06T7/00;G06T7/60 |
主分类号 |
G06T7/00 |
代理机构 |
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代理人 |
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