METHODS FOR LOWERING HIF-1 MEDIATED GENE EXPRESSION

摘要

The present invention relates to the elucidation of specific molecular features of endogenous amino acids and their derivatives for inhibiting hypoxia-inducible gene expression by preventing inactivation of hypoxia-inducible factor hydroxylating enzymes. This invention encompasses agents that can be used to reduce tissue vascularization, cancer cell survival, and to treat obesity.