| 摘要 |
A stilbene-based compound having hepatoprotective activity and a preparation method thereof are provided to maintain the shape, structure and physiological function of the liver, prevent liver disease, inhibit progress of the liver disease, and treat liver disease based on the natural restoration ability of the liver without side effects. A hepatoprotective composition comprises the stilbene-based compound represented by the formula(I), wherein the stilbene-based compound is isolated from the organic solvent extract of Morus bombycis koizumi root; and the organic solvent is C1-C6 alcohol such as methanol. The method for preparing 2,5'-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene comprises the steps of: (a) extracting Morus bombycis koizumi with an organic solvent; and (b) separating 2,5'-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene from the extract of Morus bombycis koizumi by subjecting the extract to absorption chromatography using MCI gel and methanol and gel filtration chromatography.
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