| 摘要 |
Methods for manufacturing 7-ethyl-10-[4-(1-pipendino)-1-piperidino]- carbonyloxy- camptothecin are described comprising reacting a mixture of 1-chlorocarbonyl-4-piperidinopiperidine hydrochloride and 7-ethyl-10- hydroxycamptothecin in a polar aprotic solvent with a base in the presence o f catalytic amounts of a N-containing cyclic organic compound having 3 to 20 carbon atoms and optionally in the presence of a water binding agent in an amount which effectively binds any water present in the above reactants and solvents, or reacting A 7-Ethyl-10-hydroxycamptothecin in a polar aprotic solvent with phosgene, trichlormethyl- chloroformate, bis(trichloromethyl)carbonate or a alternative to phosgene an d a base in the presence of catalytic amounts of a N-containing cyclic organic compound havi ng 3 to 20 carbon atoms and subsequently B with piperidinopiperidine and an amine base
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