摘要 |
<p>This invention generally relates to use of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one represented by formula 1 as a chemosensitizer that enhances the efficacy of cytotoxic drugs or radiotherapy. This invention provides pharmaceutical combinations of 8-fluoro-2{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, or a pharmaceutically acceptable salt thereof and at least one additional therapeutic agent, kits containing such combinations and methods of using such combinations to treat subjects suffering from diseases such as cancer.</p> |
申请人 |
PFIZER, INC.;CANCER RESEARCH TECHNOLOGY LIMITED |
发明人 |
STEINFELDT, HEIDI;BORITZKI, THEODORE;CALVERT, ALAN, HILARY;CURTIN, NICOLA, JANE;DEWJI, MOHAMED;HOSTOMSKY, ZDENEK;JONES, CHRISTOPHER;KAUFMAN, RHONDA;KLAMERUS, KAREN;NEWELL, DAVID, RICHARD;PLUMMER, ELIZABETH, RUTH;REICH, STEVEN, DAVID;STRATFORD, IAN, J.;THOMAS, HUW, DAVID;WILLIAMS, KAYE, JANINE |