发明名称 |
Proteomic screening for redox state dependent protein-protein interactions |
摘要 |
This invention provides a modified yeast two-hybrid system in order to identify NO-dependent protein-protein interactions. Bait proteins implicated in apoptotic signaling pathways were used to identify NO-dependent interactions. The physiological relevance of these interactions is demonstrated by their occurrence and dependence on endogenous NO in mammalian cells, and by the functional interrelatedness of bait and prey.
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申请公布号 |
US7229762(B2) |
申请公布日期 |
2007.06.12 |
申请号 |
US20030378419 |
申请日期 |
2003.03.03 |
申请人 |
DUKE UNIVERSITY MEDICAL CENTER |
发明人 |
STAMLER JONATHAN S.;MATSUMOTO AKIO |
分类号 |
C12Q1/68;C12N5/00;C12N5/02;C12N15/63;C12Q1/26;C40B30/04;G01N33/50;G01N33/53;G01N33/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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