发明名称 |
Method of constructing a synthetic polynucleotide |
摘要 |
A method of constructing a synthetic polynucleotide, the method including selecting a first codon of a parent polynucleotide that encodes a polypeptide for replacement with a synonymous codon, wherein the synonymous codon is selected on the basis that it exhibits a higher translational efficiency in an epithelial cell of a mammal than the first codon in a comparison of translational efficiencies of codons in test cells of the same type as the epithelial cell; and replacing the first codon with the synonymous codon to construct the synthetic polynucleotide. |
申请公布号 |
US7229761(B2) |
申请公布日期 |
2007.06.12 |
申请号 |
US20020305765 |
申请日期 |
2002.11.27 |
申请人 |
THE UNIVERSITY OF QUEENSLAND |
发明人 |
FRAZER IAN HECTOR;ZHOU, DECEASED JIAN;SUN, LEGAL REPRESENTATIVE XIAO YI |
分类号 |
C12Q1/68;C07K14/025;C07K14/435;C12N7/02;C12N15/67;C12N15/85 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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