| 摘要 |
A composition comprising 3-lyso-2-phosphatidylcholine or its derivatives is provided to prevent and treat septic shock, and reduce death rate of patients by septic shock through administering the composition into a septic shock patient orally or non-orally. The composition for preventing and treating septic shock comprises 3-lyso-2-phosphatidylcholine represented by the formula(1) or its derivatives, wherein the 3-lyso-2-phosphatidylcholine derivatives are ether analogues of 3-lyso-2-phosphatidylcholine represented by the formula(2); R1 or R2 is C4-30 alkyl or C4-30 alkenyl having one or more of double bonds; the ether analogues of 3-lyso-2-phosphatidylcholine include L-alpha-3-lyso-2-phosphatidylcholine, gamma-O-alk-1-enyl; L-alpha-3-lyso-2-phosphatidylcholine, gamma-O-alkyl; DL-alpha-3-lyso-2-phosphatidylcholine, gamma-O-hexadecyl; and L-alpha-3-lyso-2-phosphatidylcholine, gamma-O-hexadecyl. The daily dosage of the composition is 0.01-100 mg/kg.
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