| 摘要 |
Compounds which are active against viruses have Formulas (1, 2, 3 and 4) wherein B is a purine or pyrimidine heterocyclic ring and is preferably selected from the group consisting of 6-aminopurine (adenine), 2,6- diaminopurine, 2-amino-6-azidopurine, 2-amino-6-cyclopropylaminopurine, 6- hydroxypurine (hypoxanthine), 2-amino-6-halo substituted purines, 2-amino-6- alkoxy substituted purines, 2-amino-6-hydroxypurine (guanine), 3-deazapurine s, 7-deaza-purines, 8-azapurines, cytosine, 5-halo substituted cytosines, 5-alk yl substituted cytosines, thymine, uracil and 6-azapyrimidines; X is O; and, R1 and R2 are alkyl or aryl groups. The compounds of the present invention also include the R- and S-enantiomers of the above compounds. The R1X and/or R2X can also be amino acid residues with X as NH.
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