发明名称 |
Assay for YKL-40 as a marker for degradation of mammalian connective tissue matrices |
摘要 |
The invention is a method of identifying the presence of a disease state in a mammal which is associated with degradation of connective tissue in the mammal which contains the protein known as YKL-40. The method is a competitive immunoassay for YKL-40. It can be used, for example, to identify the presence of inflammatory or degenerative joint disease and tumor metastasis (to the extent it can be correlated to serum YKL-40 levels). Serum YKL-40 levels as detected and quantified by the inventive method are also suggestive of the prognosis for the length of survival in breast cancer patients following recurrence and/or metastasis of their cancers.
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申请公布号 |
US7230086(B2) |
申请公布日期 |
2007.06.12 |
申请号 |
US20030648811 |
申请日期 |
2003.08.25 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
PRICE PAUL A.;JOHANSEN JULIA S. |
分类号 |
C07K16/00;G01N33/53;A61K38/00;A61K39/395;A61P29/00;A61P43/00;C07K14/47;C07K16/18;G01N33/564;G01N33/574;G01N33/577;G01N33/68 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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