MAGNETIC RESONANCE IMAGING CONTRAST AGENTS CONTAINING WATER-SOLUBLE NANOPARTICLES OF MANGANESE OXIDE OR MANGANESE METAL OXIDE

摘要

An MRI(magnetic resonance imaging) contrast agent is provided to have an excellent magnetic properties and excellent MRI contrast effects, and significantly improve the magnetic resonance imaging diagnosis effect due to high stability in an aqueous solution. The MRI contrast agent comprises water soluble manganese oxide or manganese metal oxide nanoparticles, wherein the manganese oxide or manganese metal oxide nanoparticles have their core consisting of 1 to 1000 nm-sized manganese-containing metal oxide nanoparticles, are represented by MnOa(0<a<=5) or MnMbOc(in which M is at least one metal atoms selected from the group consisting of a Group 1 or 2 element such as Li, Na, Be, Ca, Ge, Mg, Ba, Sr and Ra, a Group 13 element such as Ga and In, a transition metal element such as Y, Ta, V, Cr, Co, Fe, Ni, Cu, Zn, Ag, Cd and Hg, and lanthanide or actinide group elements such as La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm and Yb, wherein 0<b<=5, and 0<c<=10) and are soluble in water themselves, or coated with a water soluble multi-functional group ligand.