发明名称 |
ADENOVIRUS 36 E4 ORF 1 GENE AND PROTEIN AND THEIR USES |
摘要 |
<p>Expression of the E4 orf 1 gene of Ad-36 alone has been discovered to be responsible for the increased insulin sensitivity observed in Ad-36 infected animals, including increased adipogenesis. Ad-36 E4 orf 1 protein can be used to increase insulin sensitivity and ameliorate diabetes. Additionally, drugs that mimic the action of Ad-36 E4 orf 1 protein could be found. Ad-36 E4 orf 1 could also be used to increase fat cells in lipodystrophy. We have also discovered that Ad-36 infection in human skeletal muscle cells increased differentiation and insulin independent glucose uptake. It is expected that infection with Ad-36 E4 orf 1 gene will also cause these effects.</p> |
申请公布号 |
CA2632013(A1) |
申请公布日期 |
2007.06.07 |
申请号 |
CA20062632013 |
申请日期 |
2006.11.30 |
申请人 |
WAYNE STATE UNIVERSITY;BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECH |
发明人 |
DHURANDHER, NIKHIL V.;HOLLAND, THOMAS C.;WANG, ZHONG Q. |
分类号 |
A01N37/18;A01N43/04 |
主分类号 |
A01N37/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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