HETEROCYCLIC-SUBSTITUTED BIS-1,8 NAPHTHALIMIDE COMPOUNDS, ANTIBODY DRUG CONJUGATES, AND METHODS OF USE

摘要

The invention relates to bis 1, 8 naphthalimide compounds including antibody
drag conjugate (ADC) compounds represented by Formula (I) : where one or more
1, 8 bis-naphthalimide drug moieties (D) having Formulas (IIa) and (IIb) are
covalently linked, through the wavy line, by a linker (L) to an antibody (Ab).
The invention also relates to heterocyclic-substituted 1, 8 bis-naphthalimide
compounds having Formula (XV). The invention also relates to pharmaceutical
compositions comprising an effective amount of a Formula (I) ADC or Formula
(XV) heterocyclic-substituted 1, 8 bis-naphthalimide compound for treatment of
hyperproliferative disorders and other disorders. The invention also relates
to methods for killing or inhibiting the proliferation of tumor cells or
cancer cells including administering to a patient an effective amount of a
Formula (I) ADC or Formula (XV) compound.