发明名称 |
METHOD FOR PREPARING IMMUNOGLOBULIN LIBRARIES |
摘要 |
The invention relates to methods of construction of human immunoglobulin libraries, by isolating B memory cells (IgM memory, class-switched or plasma blast cells) . The libraries are generated on the surface of replicable genetic packages, such as phages. It also relates to methods of screening said libraries and the immunoglobulins identified in said screenings. Additionally, the invention relates to human binding molecules that bind to H5N1 virus, in particular antibodies and immunoconjugates. Pharmaceutical compositions comprising said binding molecules are also disclosed. |
申请公布号 |
WO2007031550(A3) |
申请公布日期 |
2007.06.07 |
申请号 |
WO2006EP66355 |
申请日期 |
2006.09.14 |
申请人 |
CRUCELL HOLLAND B.V.;THROSBY, MARK;DE KRUIF, CORNELIS ADRIAAN;BAKKER, ADRIANUS QUIRINUS |
发明人 |
THROSBY, MARK;DE KRUIF, CORNELIS ADRIAAN;BAKKER, ADRIANUS QUIRINUS |
分类号 |
C07K16/18;A61K39/42;C07K16/10;C40B40/02 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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