发明名称 |
Novel cofactor that modulates steroid receptor activities |
摘要 |
The invention provides a new glucocorticoid receptor coactivator named STAMP (Steroid receptor coactivator-1 and Transcription intermediary factor-2 Associated Modulatory Protein) that can modulate transcription of glucocorticoid-, progesterone-, mineralocorticoid- and androgen-responsive genes. The invention also provides antibodies that can bind STAMP and modulate its activity. In addition, the invention provides antisense, ribozyme and siRNA STAMP nucleic acids that can modulate the expression of STAMP. Also provided are compositions and methods for modulating glucocorticoid-responsive gene expression and for treating a variety of diseases and conditions.
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申请公布号 |
US2007128627(A1) |
申请公布日期 |
2007.06.07 |
申请号 |
US20060510859 |
申请日期 |
2006.08.25 |
申请人 |
SIMONS S S JR;HE YUANZHENG |
发明人 |
SIMONS S. S.JR.;HE YUANZHENG |
分类号 |
C12Q1/68;A61K38/00;C07H21/04;C07K14/47;C07K14/705;C07K14/715;C12P21/06 |
主分类号 |
C12Q1/68 |
代理机构 |
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地址 |
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