BACTERIAL VACCINE AGAINST BACTERIAL INFECTIVE AGENTS, TO BE USED IN ANIMALS

摘要

The invention relates to a bacterial vaccine to be used in an animal, especially a working animal. Said bacterial vaccine contains at least one bacterial infective agent of the working animal with at least one respective knockout mutation in at least three different chromosomal genes, at least one gene coding for an immunogenic protein used as a marker in the bacterial infective agent. Said immunogenic protein used as a marker produces antibodies which are not required for providing protective immunity to the animal. The invention also relates to a bacterium that is used in the vaccine, immunogenic proteins which are not essential for immune protection, the modified nucleic acids thereof, and a diagnostic method for serologically determining infected and vaccinated animals.