| 摘要 |
Recently it has been proved that therapeutic agents could reach CNS directly form the nasal olfactory mucosa and trigeminal branches bypassing the blood brain barrier (BBB). Poor accessibility to the olfactory region and the upper nasal cavity, short retention time over the mucosa and small dose size unable to achieve therapeutic concentrations in CSF are form the major obstaceles in the way of this route, the INS - Intra-Nasal Suppository- Project (BRAINSHIP-1) is a design of a semisolid dosage form for nasal amdinstration to overcome these obstacles. INS is formed of two parts: .) Inner part of dimensions capable of accessing to the olfactory region and upper nasal cavity through the inner nasal valve carrying sufficient dose. .) Outer belt (4) adheres to valve orifice after molting of the suppository into the upper nasal cavity to prevent relapse of the ingredients until complete melting or dissolution and absorption. This design theoretically offers accessibility, long retention thme and high dose.
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