BALANCED TRANSLOCATION IN COMPARATIVE HYBRIDIZATION

摘要

The present invention provides comparative genomic hybridization methods for detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. The method includes hybridization with one or more probes for detecting balanced translocations. Such probes may be complementary to the moving genome segment which is translocated or may be complementary to the translocation break point.