An inhalable dry powder formulation containing SAE-CD and an active agent is provided. The formulation is adapted for administration by DPI. The SAE-CD serves as a carrier rather than as an absorption enhancer. The average particle size of the SAE-CD is large enough to preclude (for the most part) pulmonary deposition thereof. Following release from the DPI device, the SAE-CD-containing particles dissociate from the active agent-containing particles in the buccal cavity or throat, after which the active agent-containing particles continue deeper into the respiratory tract. The physicochemical and morphological properties of the SAE-CD are easily modified to permit optimization of active agent and carrier interactions. Drugs having a positive, neutral or negative electrostatic charge can be delivered by DPI when SAE-CD is used as a carrier.
申请公布号
WO2005104712(A3)
申请公布日期
2007.06.07
申请号
WO2005US14010
申请日期
2005.04.22
申请人
CYDEX, INC.;PIPKIN, JAMES, D.;ZIMMERER, RUPERT, O.;HICKEY, ANTHONY, J.;THOMPSON, DIANE, O.;SMYTH, HUGH, D., C.
发明人
PIPKIN, JAMES, D.;ZIMMERER, RUPERT, O.;HICKEY, ANTHONY, J.;THOMPSON, DIANE, O.;SMYTH, HUGH, D., C.