| 摘要 |
<p>Provided are pranlukast-containing granules, comprising: a granular core; and a drug coating layer which comprises pranlukast, a water-soluble polymer, and a surfactant, and is formed on the granular core, and a process for preparing the same. The granules, in which the surface of pranlukast is modified (or coated) with a surfactant, can improve the adhesiveness and solubility of pranlukast and increase the dissolution rate and bioavailability of pranlukast, and thus, can be administered at a remarkably decreased dose relative to conventional formulations. Furthermore, the granules can be prepared in the absence of an organic solvent, thereby enabling large-scale mass production without a toxicity problem of residual solvent.</p> |
