METHODS FOR PRODUCTION OF RECEPTOR AND LIGAND ISOFORMS
摘要
Provided are methods for production of cell surface receptor (CSR) and ligand isoforms. In particular, isoform fusions that a precursor sequence for secretion, processing and intracellular trafficking are provided. Nucleic acid molecules encoding the fusions are expressed in a host cell and the encoded and partially or completely processed encoded CSR or ligand isoforms is produced in the cell culture medium. The resulting polypeptide optionally includes an epitope tag for the detection and/or purification thereof.
申请公布号
WO2007064437(A2)
申请公布日期
2007.06.07
申请号
WO2006US42680
申请日期
2006.10.31
申请人
RECEPTOR BIOLOGIX, INC.;JIN, PEI;SHEPARD, H., MICHAEL;GORMAN, CORNELIA;ZHANG, JUAN
发明人
JIN, PEI;SHEPARD, H., MICHAEL;GORMAN, CORNELIA;ZHANG, JUAN