METHODS AND SYSTEM FOR DETERMINING BRAIN COMPLIANCE

摘要

Systems and methods for measuring intracranial pressure and brain compliance are provided. In one aspect, for example, a method for noninvasive measurement of brain compliance in a subject may include calculating a phase shift between an intracranial pulsatile perfusion flow measured from the subject and an extracranial pulsatile perfusion flow measured from the subject, and determining brain compliance of the subject from the phase shift between the intracranial pulsatile perfusion flow and an extracranial pulsatile perfusion flow. Though various methods of calculating phase shift are contemplated, in one aspect such a calculation may include calculating an intracranial frequency waveform corresponding to the intracranial pulsatile perfusion flow, calculating an extracranial frequency waveform corresponding to the extracranial pulsatile perfusion flow, and calculating a phase difference between the intracranial frequency waveform and the extracranial frequency waveform.