发明名称 |
Intercalators having affinity for DNA and methods of use |
摘要 |
Intercalator compounds are provided which are comprised of intercalator moieties, or substituted intercalator moieties, having one or more functionalized chains, or moieties, and which compounds provide a high affinity for binding to the DNA molecule and show reduced self-quenching, while providing superior transport kinetics. The compounds have been found to provide enhanced fluorescence when bound to a DNA molecule within a fluorescent flow cytometry environment which is about eight to ten times brighter in fluorescence than "bis" structure conventional intercalating agents and other known intercalating agents utilized in flow cytometry environment.
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申请公布号 |
EP1792897(A2) |
申请公布日期 |
2007.06.06 |
申请号 |
EP20070101154 |
申请日期 |
1994.06.23 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
BIENIARZ, CHRISTOPHER;HUFF, JEFFREY, BRUCE;HENRARD, DENIS, R. |
分类号 |
C07D219/10;C07D221/12;C07D209/82;C07D219/14;C07D401/02;C07D401/06;C07D403/06;C07D413/06;C07D413/12;C07D413/14;C07D417/06;C07D417/14;C09K11/06 |
主分类号 |
C07D219/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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