摘要 |
There is provided a process for preparing a carboxylic acid ester of formula (3):
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ R 2 COOR 1 €ƒ€ƒ€ƒ€ƒ€ƒ(3)
wherein R 1 is
an alkyl group which may be substituted,
an alkenyl group which may be substituted,
an alkynyl group which may be substituted,
an aralkyl group which may be substituted, or
a heteroarylalkyl group which may be substituted,
and R 2 is
an alkyl group which may be substituted,
an alkenyl group which may be substituted,
an alkynyl group which may be substituted,
an aryl group which may be substituted,
a heteroaryl which may be substituted,
an aralkyl group which may be substituted, or
a heteroarylalkyl group which may be substituted, which process is characterized by the steps of reacting a monohydroxy compound of formula (1):
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ R 1 OH€ƒ€ƒ€ƒ€ƒ€ƒ(1)
wherein R 1 is as defined above, with a zirconium compound of formula (6):
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ Zr(OR 8 ) 4 €ƒ€ƒ€ƒ€ƒ€ƒ(6)
wherein R 8 is an alkyl group or an aryl group which may be substituted and is not the same as R 1 , to prepare a zirconium catalyst, and reacting a carboxylic acid of formula (2):
€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ R 2 COOH€ƒ€ƒ€ƒ€ƒ€ƒ(2)
wherein R 2 is as defined above, with the monohydroxy compound of formula (1) in the presence of the zirconium catalyst. |